Isao Nagaoka Selected Research

Glucosamine (Dona)

7/2020	Citrulline cooperatively exerts an anti-inflammatory effect on synovial cells with glucosamine and N-acetylglucosamine.
7/2019	Chondroprotective action of glucosamine, a chitosan monomer, on the joint health of athletes.
3/2013	Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers.
10/2012	Evaluation of the effect of methionine and glucosamine on adjuvant arthritis in rats.
3/2012	Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study.
1/2012	Biological activities of glucosamine and its related substances.
9/2011	Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation.
9/2011	Effect of a glucosamine-based combination supplement containing chondroitin sulfate and antioxidant micronutrients in subjects with symptomatic knee osteoarthritis: A pilot study.
6/2011	Effects of glucosamine derivatives and uronic acids on the production of glycosaminoglycans by human synovial cells and chondrocytes.
3/2010	Evaluation of the effect of glucosamine on an experimental rat osteoarthritis model.

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Isao Nagaoka Research Topics

Disease

23	Sepsis (Septicemia) 05/2021 - 01/2005
19	Inflammation (Inflammations) 01/2021 - 04/2002
17	Neoplasms (Cancer) 09/2019 - 02/2006
14	Colorectal Neoplasms (Colorectal Cancer) 09/2019 - 12/2002
14	Osteoarthritis 07/2019 - 04/2002
9	Septic Shock (Toxic Shock Syndrome) 06/2017 - 09/2002
8	Knee Osteoarthritis 11/2017 - 09/2010
8	Infections 02/2016 - 03/2004
4	Disseminated Intravascular Coagulation 01/2021 - 05/2013
4	Pain (Aches) 07/2017 - 09/2010
4	Arthritis (Polyarthritis) 04/2017 - 04/2002
4	Atherosclerosis 01/2011 - 07/2004
4	Skin Diseases (Skin Disease) 01/2009 - 08/2005
3	Bacterial Infections (Bacterial Infection) 05/2021 - 01/2002
3	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 03/2017
3	Astrocytoma (Pilocytic Astrocytoma) 01/2020 - 03/2017
3	Necrosis 04/2016 - 03/2004
3	Acute Lung Injury 07/2014 - 08/2011
3	Pneumonia (Pneumonitis) 07/2014 - 09/2003
3	Bone Resorption 03/2013 - 02/2011
3	Wounds and Injuries (Trauma) 06/2012 - 01/2006
3	Synovitis 05/2012 - 02/2011
3	Acute Promyelocytic Leukemia 12/2007 - 02/2006
2	Mycoses (Diseases, Fungus) 05/2021 - 04/2009
2	Joint Diseases (Joint Disease) 07/2020 - 06/2011
2	type 2C Congenital disorder of glycosylation 12/2018 - 04/2010
2	Osteoporosis 01/2018 - 05/2015
2	Disease Progression 11/2017 - 08/2011
2	Leukemia 01/2017 - 08/2002
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 07/2014 - 08/2011
2	Body Weight (Weight, Body) 10/2012 - 03/2011
2	Reperfusion Injury 04/2010 - 12/2005
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 09/2008 - 08/2008
2	Rupture 02/2008 - 12/2006
1	Endotoxemia 05/2021

Drug/Important Bio-Agent (IBA)

14	Glucosamine (Dona)IBA 07/2020 - 04/2002
12	Fluorouracil (Carac)FDA LinkGeneric 09/2019 - 06/2006
10	Biomarkers (Surrogate Marker)IBA 05/2021 - 03/2010
10	CytokinesIBA 08/2020 - 01/2002
10	CollagenIBA 04/2019 - 12/2005
10	Peptides (Polypeptides)IBA 06/2017 - 09/2002
9	Collagen Type II (Type II Collagen)IBA 07/2019 - 03/2010
8	Pharmaceutical PreparationsIBA 05/2021 - 01/2007
8	LipopolysaccharidesIBA 08/2020 - 01/2005
7	EndotoxinsIBA 05/2021 - 01/2005
7	AntithrombinsIBA 12/2020 - 05/2013
7	CathelicidinsIBA 10/2020 - 09/2002
6	Interleukin-6 (Interleukin 6)IBA 07/2020 - 07/2008
6	Oxaliplatin (Eloxatin)FDA LinkGeneric 02/2019 - 03/2010
6	Leucovorin (Folinic Acid)FDA Link 02/2019 - 03/2010
6	Hyaluronic Acid (Hyaluronan)IBA 10/2012 - 09/2010
5	Irinotecan (Camptosar)FDA LinkGeneric 02/2019 - 03/2010
5	HMGB1 Protein (HMG1)IBA 06/2017 - 03/2009
4	Dacarbazine (DIC)FDA LinkGeneric 01/2021 - 05/2013
4	Biological ProductsIBA 08/2020 - 02/2008
4	AcetylglucosamineIBA 07/2020 - 09/2016
4	Interleukin-8 (Interleukin 8)IBA 01/2020 - 08/2008
4	ChemokinesIBA 06/2017 - 03/2007
4	IronIBA 11/2014 - 04/2008
4	EnzymesIBA 06/2011 - 06/2006
4	Proteins (Proteins, Gene)FDA Link 01/2011 - 10/2006
3	Proteoglycans (Proteoglycan)IBA 07/2017 - 03/2010
3	ThrombomodulinIBA 06/2017 - 04/2014
3	Matrix Metalloproteinases (MMPs)IBA 06/2017 - 12/2006
3	Histones (Histone)IBA 12/2015 - 01/2013
3	GalactosamineIBA 03/2011 - 08/2009
3	MacrolidesIBA 03/2009 - 07/2002
3	TransferasesIBA 07/2006 - 12/2002
2	InterleukinsIBA 01/2020 - 11/2017
2	Substance PIBA 01/2020 - 03/2017
2	FlavonoidsIBA 01/2019 - 01/2011
2	Teriparatide (Parathar)FDA Link 01/2018 - 05/2015
2	Paclitaxel (Taxol)FDA LinkGeneric 09/2017 - 07/2017
2	Tolonium Chloride FDA Link 06/2017 - 03/2010
2	DNA (Deoxyribonucleic Acid)IBA 07/2014 - 01/2013
2	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2014 - 01/2014
2	AnticoagulantsIBA 01/2014 - 05/2013
2	ProstaglandinsIBA 10/2012 - 09/2003
2	Chondroitin Sulfates (Chondroitin Sulfate)IBA 03/2012 - 09/2011
2	AntioxidantsIBA 09/2011 - 01/2011
2	LipidsIBA 03/2011 - 01/2011
2	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 08/2008 - 09/2003
2	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoproteinIBA 12/2007 - 10/2006
2	beta-DefensinsIBA 03/2007 - 01/2002
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2006 - 11/2005
2	Superoxides (Superoxide)IBA 07/2004 - 08/2002
2	Chemotactic FactorsIBA 03/2004 - 04/2002
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2004 - 09/2002
1	GlucansIBA 05/2021
1	Thrombin FDA Link 01/2021
1	Anti-Infective Agents (Microbicides)IBA 08/2020
1	CitrullineIBA 07/2020

Therapy/Procedure

11	Therapeutics 01/2021 - 01/2009
8	Drug Therapy (Chemotherapy) 09/2019 - 03/2010
3	Oral Administration 10/2017 - 06/2017
2	Punctures 10/2020 - 01/2016
2	Ligation 10/2020 - 01/2016
2	Intravenous Infusions 07/2014 - 04/2014
2	Esophagectomy 07/2014 - 08/2011
2	Adjuvant Chemotherapy 07/2006 - 06/2006